Business

Moderna-Merck may spark cancer vaccine wave

By Sohail Khan 20 August 2026, 11:00 am

Benchmarks
Nifty24,205.85127.55

FEATURED FUNDS★★★★★

Motilal Oswal Midcap Fund Direct-Growth

5Y Return
23.26 %

Invest Now

Enter search text:

Business News›Industry›Healthcare/Biotech›Healthcare›Moderna, Merck breakthrough could usher in wave of cancer vaccines

Read Today's Paper

Moderna, Merck breakthrough could usher in wave of cancer vaccines

Synopsis

Merck and Moderna's personalized cancer vaccine shows promise for melanoma patients. This new treatment trains the immune system to target specific tumor mutations. The vaccine, combined with Keytruda, significantly reduced cancer recurrence in trials. Doctors are hopeful this approach will expand to treat many other cancer types. Further trials are underway for lung, bladder, kidney, pancreatic, and stomach cancers.

cervical cancer vaccine — Representative image.

Merck and Moderna's success with a personalized cancer vaccine designed to keep melanoma at bay opens a new avenue of treatment that doctors hope will work against many types of tumors.

Unlike chemotherapy, which kills both healthy and cancerous cells, or immunotherapy, which revs up the immune system, personalized cancer vaccines train the immune system to specifically target mutations found only on a person's tumor. Merck and Moderna said on Wednesday their vaccine helped prevent the return and spread of disease in a large trial involving more than 1,000 melanoma ‌patients. They had localized ⁠tumors that were ⁠removed surgically, but had a high risk of recurrence. Moderna expects that thousands of melanoma patients could benefit within the first few years of approval.

"It is a big deal for the field in general," said Dr. Ryan Sullivan, director of the Center for Melanoma at Mass General Brigham Cancer Institute. "With this positive study, there is hope (and likely investment to follow) that these approaches may change the way we treat cancer more broadly."

The trial result is "a monumental leap forward," validating mRNA technology as a cancer treatment, said Dr. Julie Gralow, chief medical officer of the American Society of Clinical Oncology.

MORE TRIALS TARGET OTHER CANCERS

Beyond melanoma, personalized cancer vaccines are in late-stage development for a host of tumor types. Merck and Moderna have several large trials under way in non-small cell lung cancers that have been surgically removed.

They are also studying the combination in mid-stage trials in patients with bladder and kidney cancers as well as in early-stage trials ⁠in pancreatic ‌and stomach cancers, with numerous trial results expected in the next year or two, Moderna President Stephen Hoge told Reuters.

Roche and BioNTech, whose mRNA technology was used in the Pfizer COVID vaccines, are testing a similar treatment called autogene cevumeran in mid-stage studies in colon and pancreatic cancer patients who have undergone surgery.

Results of the ⁠colon cancer trial are expected in 2027, with pancreatic trial results to follow in 2031.

"We should be hearing results from multiple studies over the next few years and there's every reason to hope now, with this news, that many of them will be positive," said Dr. Robert Vonderheide, director of Penn Medicine's Abramson Cancer Center and president-elect of the American Association for Cancer Research.

HOW IT WORKS

Merck and Moderna's treatment, known as intismeran autogene, involves activating the immune system with up to nine doses of Merck's immunotherapy drug Keytruda, infused every six weeks, plus up to nine doses of a customized mRNA vaccine that instructs the immune system to attack the patient's specific cancer cells.

When used alone after surgery to reduce the risk that melanoma returns, Keytruda is given every three to six weeks for up to a year.

In melanoma patients, Keytruda treatment can result in fatigue, diarrhea, rash and inflammation of joints and muscles, as well as of healthy organs in some cases. The companies said they ‌saw no new side effects with the addition of the vaccine.

The trial is ongoing and the companies have not released full results. They will continue to follow volunteers to determine whether the drug extends overall survival.

Five-year data from a previous mid-stage trial presented in June showed the vaccine had cut the risk that the cancer would return by half, and reduced the ⁠risk that it would spread to new locations by 59% compared with Keytruda alone.

In that trial, the addition of an mRNA vaccine also showed no new increase in the rate of serious side effects.

"What we saw in the (mid-stage trial) were the kinds of reactions people were having when they got a flu or COVID shot or any other vaccine," Hoge said.

Dr. Elizabeth Buchbinder, a melanoma specialist at the Mass General Brigham Cancer Institute, said doctors treating patients whose cancer has been surgically removed often weigh the benefits of treating with Keytruda against the risk of side effects, especially for patients with only a 20% risk of cancer recurrence.

The added benefit of the vaccine, however, "may change that math," she said.

Buchbinder said a key reason to select melanoma to test in combination with Keytruda was that it is a tumor that produces a lot of mutations, making it easier for the immune system to spot.

Many other cancer types also produce multiple mutations, she said, suggesting it may have broad applicability.

"We'll see, but it's definitely an area that is going to be exploding, especially with these results coming out," she said.

Add as a Reliable and Trusted News Source
Add Now!

(You can now subscribe to our WhatsApp channel)

(Catch all the Business News, Breaking News and Latest News Updates on The .)

…moreless

(You can now subscribe to our WhatsApp channel)

Read More News on
personalized cancer vaccinesModerna cancer vaccinemelanoma researchmRNA cancer therapycancer clinical trialsMerck melanoma treatmentcancer recurrence preventionintismeran autogeneKeytruda immunotherapy

(Catch all the Business News, Breaking News and Latest News Updates on The .)

…moreless

Enter search text:

Continue reading with one of these options:
Limited Access
Free
Login to get access to some exclusive stories

& personalised newsletters
Login Now

Unlimited Access
Starting @ Rs120/month
Get access to exclusive stories, expert opinions &

in-depth stock reports
Subscribe Now

Unlock Access to All Exclusives with ETPrime FREE TRIAL

15 Days Free: Unlock All ETPrime Exclusives, Market Tools & ePapers

Trial offer expiring in00 : 05 : 00

I'd rather pay ₹2599 now

Uh-oh! This is an exclusive story available for selected readers only.

Worry not. You’re just a step away.

Prime Account Detected!

It seems like you're already an ETPrime member with

Log out of your current logged-in account and log in again using your ET Prime credentials to enjoy all member benefits.

Unlock ETPrime's Exclusive Stories Today!

Subscribe to gain powerful insights on business, stock market and industry trends.

Big Price Drop! Flat 40% Off

Student Only Offer

Already a Member? Sign In now

Already a Member? Sign In now
Already a Member? Sign In now

Offer Exclusively For You

Save up to Rs. 700/-

ON ET PRIME MEMBERSHIP

Avail Offer

Offer Exclusively For You

Get 1 Year Free

With 1 and 2-Year ET prime membership

Avail Offer

Offer Exclusively For You

Get 1 Year Free

With 1 and 2-Year ET prime membership

Avail Offer

Offer Exclusively For You

Get Flat 40% Off

Then ₹ 1749 for 1 year

Avail Offer

Offer Exclusively For You

ET Prime at ₹ 49 for 1 month

Then ₹ 1749 for 1 year

Avail Offer

Special Offer

Get flat 40% off on ETPrime

Avail Offer
Avail Offer

Claim NowAlready a Member? Sign In now

Need Assistance?

Connect with an ETPrime expert for personalized support and guidance

+91 9484700004

' + h3 + '

' + h4 + '

' + listing + '

What’s Included with

ETPrime Membership

1Exclusive Insights That Matter

Uncover the truth with our investigative stories

Make strategic moves using the real-world case studies

Read industry-specific stories to identify emerging trends

Spot opportunities with in-depth insights that matter

Trump temper on H-1B visas is forcing Indians to do these things to stay put in US

What Adani’s US indictment means for India Inc’s overseas fundraising
Why veterans like Reliance, L&T are on acquisition spree? Aswath Damodaran has an answer.

Will China’s dollar bond sale in Saudi Arabia trump the US in financial world?
Huawei launches its own OS to compete with Google and Apple. But can it win beyond China?

The problem with lab grown diamonds
Why a falling rupee is a better option for the economy

A list of top 20 momentum stocks that have delivered massive returns in one year